Depp’s professional break came in 1987 with the premiere of 21 Jump Street, a television police series that starred Depp as Officer Tom Hanson, a young cop who frequently went undercover in high schools and colleges to catch troubled youths. The show was a hit, though Depp resented his promotion as a teen heartthrob. In 1990 he left the series and appeared in John Waters’s Cry-Baby and Tim Burton’s Edward Scissorhands, two films by maverick directors that showcased Depp’s range. Scissorhands began a long association between the actor and director that led to Depp’s appearance in several other Burton films, including Ed Wood (1994), Sleepy Hollow (1999), and Charlie and the Chocolate Factory (2005); in the latter film Depp played the reclusive candy baron Willy Wonka. In addition, Depp provided the voice of the unfortunate groom in Burton’s macabre animated tale Corpse Bride (2005).

Depp continued to show his versatility with roles as a 19th-century accountant in Jim Jarmusch’s Dead Man (1995) and as an FBI agent who infiltrates the Mafia in Donnie Brasco (1997). In 1998 Depp, a longtime friend and fan of gonzo journalist Hunter S. Thompson, starred in Terry Gilliam’s Fear and Loathing in Las Vegas, a film based on Thompson’s pseudo-autobiographical novel of the same name; Depp later received top billing in another Thompson adaptation, The Rum Diary (2011). He interviewed gonzo artist Ralph Steadman, who illustrated much of Thompson’s work, in the documentary For No Good Reason (2012). Other notable films include Roman Polanski’s The Ninth Gate (1999) and Ted Demme’s Blow (2001).